Health Systems as we know is very complex and the manager of the system has to know information and possess competence. It does not rest on one person but a team of transdisciplinary experts. Where does and how does pharmacovigilance play a critical role in managing this complex health system? At the end of this pre-conference education-workshop, the manager is expected to know and apply PV in their work, with the goal of improving patient and societal health outcomes. The course will take a systems approach in the design. In the governance of health service, we look at how PV is helping public health programs both in the communicable and in the non-communicable disease sector and call for improvements. But health services are diverse and hence we need to ensure that there is a responsive health transdisciplinary human resources able to function as a team anchored with common drug safety principles. Necessarily, a manager will then have to appreciate drug benefits and risks and how will this trade off in decision making happen – it will require a scientific approach like health technology assessments and an ethical framework. Lastly, as disinformation and misinformation is on the rise, the health manager will need to know how to apply PV to correct such harm such as creating literacy interventions.